Fragmentation of doubly-protonated Pro-His-Xaa tripeptides: Formation of b 2 2+ ions
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چکیده
منابع مشابه
Comparing the gas-phase fragmentation reactions of protonated and radical cations of the tripeptides GXR
Electrospray ionization (ESI) mass spectrometry of methanolic solutions of mixtures of the copper salt (2,2′:6′,2′′-terpyridine)copper(II) nitrate monohydrate ([Cu(II)(tpy)(NO3)2]·H2O) and a tripeptide GXR (where X = 1 of the 20 naturally occurring amino acids) yielded [Cu(II)(tpy)(GXR)]•2+ ions, which were then subjected to collision induced dissociation (CID). In all but one case (GRR), these...
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Protonated a(2) and a(3) (therefore doubly charged) ions in which both charges lie on the peptide backbone are formed in collision-induced dissociations of [La(III)(peptide)(CH(3)CN)(m)](3+) complexes. Abundant (a(3)+H)(2+) ions are formed from triproline (PPP) and peptides with a proline residue at the N-terminus; these peptides are the most effective in producing ions of the type (a(2)+H)(2+)...
متن کاملFragmentation pathways of protonated peptides.
The fragmentation pathways of protonated peptides are reviewed in the present paper paying special attention to classification of the known fragmentation channels into a simple hierarchy defined according to the chemistry involved. It is shown that the 'mobile proton' model of peptide fragmentation can be used to understand the MS/MS spectra of protonated peptides only in a qualitative manner r...
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Doubly-protonated bradykinin (RPPGFSPFR) and an angiotensin III analogue (RVYIFPF) were subjected to hydrogen/deuterium (H/D) exchange with CD(3)OD in a Fourier transform ion cyclotron resonance (FT-ICR) mass spectrometer. A bimodal distribution of deuterium incorporation was present for bradykinin after H/D exchange for 90 s at a CD(3)OD pressure of 4 x 10(-7) Torr, indicating the existence of...
متن کاملPreferential Fragmentation of Protonated Gas-Phase Peptide Ions Adjacent to Acidic Amino Acid Residues
Matrix-assisted laser desorptiodionization (MALDI) is an effective method for producing protonated peptide and protein ions in the gas phase.' Together with electrospray ionization, MALDI has become an ionization method of choice for analyzing peptides and proteins by mass spectrometry (MS).2 The analyses are usually carried out by measuring the molecular masses of the intact polypeptides or pe...
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ژورنال
عنوان ژورنال: Journal of the American Society for Mass Spectrometry
سال: 2009
ISSN: 1044-0305,1879-1123
DOI: 10.1016/j.jasms.2009.07.002